H. Asai et al., GENOMIC STRUCTURE AND TRANSCRIPTION OF A MURINE ODORANT RECEPTOR GENE- DIFFERENTIAL INITIATION OF TRANSCRIPTION IN THE OLFACTORY AND TESTICULAR CELLS, Biochemical and biophysical research communications, 221(2), 1996, pp. 240-247
We have characterized genomic structure and transcription of a murine
odorant receptor (OR) gene, MOR23. This gene has two distinct transcri
ptional initiation regions, which are differentially utilized in the o
lfactory and testicular cells. We have found that the MOR23 gene has a
n intron within the 5'-untranslated region upstream of the coding sequ
ence. In olfactory cells, transcription of the gene is initiated in th
e region upstream of this intron, while in testicular cells, transcrip
tion starts within the intron. Differential initiation of transcriptio
n is discussed in the context of tissue-specific expression of the OR
genes. (C) 1996 Academic Press, Inc.