UNRELATED BONE-MARROW TRANSPLANTATION IN A WISKOTT-ALDRICH SYNDROME PATIENT SHARING 2 HLA-EXTENDED HAPLOTYPES WITH THE DONOR

We report a case of BMT from an unrelated donor (MUD) in a patient aff ected by Wiskott-Aldrich syndrome (WAS). The donor-recipient pair was completely identical for two HLA-extended haplotypes. The conditioning regimen consisted of Bu 14 mg/kg followed by CY 200 mg/kg. GVHD proph ylaxis was carried out with CsA plus short-term MTX. Allogeneic engraf tment was obtained without any signs of acute or chronic GVHD, At fift een months from the transplant the patient was in an excellent clinica l condition. This case confirms the role of BMT from MUD in WAS, and s uggests that complete donor-recipient identity for two entire HLA-exte nded haplotypes is a particularly favorable immunogenetical condition in this type of transplant.