EI-1507-1 AND EI-1507-2, NOVEL INTERLEUKIN-1-BETA CONVERTING-ENZYME INHIBITORS PRODUCED BY STREPTOMYCES SP E-1507

Authors
TSUKUDA E TANAKA T OCHIAI K KONDO H YOSHIDA M AGATSUMA T SAITOH Y TESHIBA S MATSUDA Y
Citation
E. Tsukuda et al., EI-1507-1 AND EI-1507-2, NOVEL INTERLEUKIN-1-BETA CONVERTING-ENZYME INHIBITORS PRODUCED BY STREPTOMYCES SP E-1507, Journal of antibiotics, 49(4), 1996, pp. 333-339
Citations number
26
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
4
Year of publication
1996
Pages
333 - 339
Database
ISI
SICI code
0021-8820(1996)49:4<333:EAENIC>2.0.ZU;2-5
Abstract
EI-1507-1 and -2, novel interleukin-1 beta converting enzyme (TCE) inh ibitors, were isolated from the culture broths of Streptomyces sp. E-1 507. EI-1507-1 and EI-1507-2 selectively inhibited the recombinant hum an ICE activity with IC50 values of 0.23 and 0.42 mu M, respectively. EI-1507-1 and EI-1507-2 also inhibited mature interleukin-1 beta secre tion from THP-1 cells with IC50 values of 1.1 and 1.4 mu M, respective ly.