SYNTHESES AND ANTIMICROBIAL ACTIVITIES OF 5-MEMBERED RING HETEROCYCLES COUPLED TO INDOLE MOIETIES

Indole-substituted oxazolidinones, oxazolones, pyrrolidinone, imidazol idinone and imidazolones were synthesized. Their inhibitory potencies towards protein kinase C and protein kinase A were determined and thei r in vitro activities against Streptomyces chartreusis, Streptomyces g riseus, Bacillus cereus, Candida albicans and Escherichia coli were ex amined. The inhibition of Streptomyces sporulation observed for some o f them could not be linked to in vitro protein kinase C inhibition. Al l proved inactive against C. albicans but three of them exhibited a ma rked activity towards E. coli. This effect extends to other Gram-negat ive bacteria.