CONDITIONING OF CYCLOPHOSPHAMIDE-INDUCED LEUKOPENIA IN HUMANS

Citation
Dw. Giang et al., CONDITIONING OF CYCLOPHOSPHAMIDE-INDUCED LEUKOPENIA IN HUMANS, The Journal of neuropsychiatry and clinical neurosciences, 8(2), 1996, pp. 194-201
Citations number
24
Categorie Soggetti
Neurosciences,"Clinical Neurology",Psychiatry
ISSN journal
08950172
Volume
8
Issue
2
Year of publication
1996
Pages
194 - 201
Database
ISI
SICI code
0895-0172(1996)8:2<194:COCLIH>2.0.ZU;2-T
Abstract
This study evaluated whether decrements in peripheral leukocyte counts induced by cyclophosphamide can be conditioned in humans. Ten subject s being treated for multiple sclerosis received four intravenous treat ments with cyclophosphamide (unconditioned stimulus) paired with a con ditioned stimulus. Subjects received conditioned stimulus plus 10 mg o f cyclophosphamide during one of the next two treatments in a double-b lind manner. Eight of 10 subjects (P = 0.044) displayed decreased peri pheral leukocyte counts following conditioned stimulus. This change ma y have resulted from classical conditioning processes.