Dw. Giang et al., CONDITIONING OF CYCLOPHOSPHAMIDE-INDUCED LEUKOPENIA IN HUMANS, The Journal of neuropsychiatry and clinical neurosciences, 8(2), 1996, pp. 194-201
This study evaluated whether decrements in peripheral leukocyte counts
induced by cyclophosphamide can be conditioned in humans. Ten subject
s being treated for multiple sclerosis received four intravenous treat
ments with cyclophosphamide (unconditioned stimulus) paired with a con
ditioned stimulus. Subjects received conditioned stimulus plus 10 mg o
f cyclophosphamide during one of the next two treatments in a double-b
lind manner. Eight of 10 subjects (P = 0.044) displayed decreased peri
pheral leukocyte counts following conditioned stimulus. This change ma
y have resulted from classical conditioning processes.