MULTIPLE-SCLEROSIS AND BIPOLAR DISORDER - A CASE-REPORT WITH AUTOPSY FINDINGS

An 81-year-old woman with postmenopausal onset of a bipolar disorder h ad multiple individual manic and depressive episodes over the span of 31 years. Autopsy disclosed widespread periventricular demyelinated pl aques. Although the late age at onset of bipolar symptoms suggested an underlying organic disorder, the multiple affective episodes and lack of additional neurological manifestations make the case atypical. The authors stress the use of modern imaging modalities such as MRI in in vestigating secondary mood disorders.