Bv. Siegel et al., GENDER DIFFERENCES IN CORTICAL GLUCOSE-METABOLISM IN ALZHEIMERS-DISEASE AND NORMAL AGING, The Journal of neuropsychiatry and clinical neurosciences, 8(2), 1996, pp. 211-214
Male Alzheimer's disease patients, studied with 18-fluoro-2-deoxygluco
se posit ron emission tomography while performing a verbal memory test
, showed a right-greater-than-left asymmetry of cortical metabolism th
at tended to be greater than that in healthy, age-matched control subj
ects. This asymmetry was absent in female patients, preliminarily sugg
esting a propensity for left hemispheric involvement in the Alzheimer'
s disease process in males.