T. Kokubo et al., SPONTANEOUS FORMATION OF BONELIKE APATITE LAYER ON CHEMICALLY TREATEDTITANIUM METALS, Journal of the American Ceramic Society, 79(4), 1996, pp. 1127-1129
Generally, artificial materials implanted into bone defects are encaps
ulated by a fibrous tissue isolating them from the surrounding bone. O
nly limited kinds of ceramics are known to bond to living bone without
forming the fibrous tissue, and already they are being used clinicall
y as important artificial bones. However, they cannot be used under hi
ghly loaded conditions, since their fracture toughnesses are not so hi
gh as that of human cortical bone. The present study shows that even p
ure titanium metal and its alloys can bond to living bone, if their su
rfaces are pretreated with alkali hydroxide solutions. Thus-treated me
tals are believed to be useful as artificial bones even under highly l
oaded conditions because of their high bone-bonding ability as well as
high fracture toughness.