Background. Perforation of the esophagus is a deadly injury that requi
res expert management for survival. Methods. We performed a retrospect
ive clinical review of 66 patients treated at Emery University affilia
ted hospitals for esophageal perforation between 1973 and 1993. Result
s. Iatrogenic perforations accounted for 48 injuries (73%), barogenic
perforations occurred in 12 patients (17%), trauma was causative in 3
(5%), and 3 patients had esophageal infection and other causes. Lower-
third injuries occurred in 43 cases (65%), middle third in 14 (21%), a
nd upper third in 9 (14%). Early contained perforations were managed s
uccessfully by limiting oral intake and giving parenteral antibiotics
in 12 patients. Cervical perforations were drained without attempt at
closure of the leak. Perforations with mediastinal or pleural coni ami
nation recognized early were managed by primary closure and drainage i
n 28 patients. Reinforcement of the primary closure using stomach fund
us, pleural, diaphragmatic, or pericardial flap was performed in 16 pa
tients. Those perforations that escaped early recognition required tho
ughtful management, using generous debridement and drainage and someti
mes esophageal resection. The esophageal T tube provided control of le
aks in 3 of these patients and was a useful adjunct. Using these manag
ement principles, we achieved a 76% survival rate for all patients. Si
x patients with perforations complicating endoesophageal management of
esophageal varices were a high-risk subset with an 83% mortality rate
. Conclusions. Esophageal perforation remains an important thoracic em
ergency. Aggressive operative therapy remains the mainstay for treatme
nt; however, conservative management may be preferred for contained pe
rforations and the esophageal T tube may be used for late perforations
.