A CASE OF CRYOFIBRINOGENEMIA RESPONSIVE TO STANOZOLOL

Cryofibrinogen is a plasma protein complex whose presence in the perip heral blood is generally asymptomatic, but may sometimes cause multipl e thromboembolism in the skin, lung and myocardium. The pathological m anifestations associated with cryofibrinogenaemia have been treated wi th plasmapheresis and fibrinolytic drugs such as streptokinase, strept odornase and/or urokinase. Good results have recently been reported wi th stanozolol. This prompted us to treat a patient suffering from cryo fibrinogenaemia with this androgenic hormone. The patient was a 66-yea r-old woman with rapidly evolving leg ulcers. Stanozolol was orally ad ministered at 4 mg b.i.d. for 5 months and then gradually reduced. Pla sma cryofibrinogen disappeared after 45 d from the start of therapy an d cutaneous ulcers healed in 5 months.