OPTIMAL REGIMES FOR LOCAL IL-2 TUMOR-THERAPY

In this report we present studies on optimal regimes for regional IL-2 therapy, focused on dose, schedule and site of injection. Original da ta obtained in 2 murine tumour models show that all 3 factors are of i mportance. Anti-tumour responses were most effective when IL-2 was adm inistered regionally 5 to 10 times, at doses ranging from 7,000 to 33, 000 IU/day every day or every other day. This resulted in cure rates o f more than 40% in mice bearing ascitic tumour that had also dissemina ted to liver and lungs. The importance of these data is discussed in t he light of previous results of our group. These results illustrate th at the doses and schedules used in this study are not effective exclus ively in these 2 tumour models but may have a more general applicabili ty. (C) 1996 Wiley-Liss, Inc.