Rationale and Objectives. We assessed the ability of a three-dimension
al (3D) ultrasound imaging system to measure accurately prostate volum
e. Methods. Multiple two-dimensional ultrasound images of cadaver pros
tates scanned in a water bath were reconstructed into three-dimensiona
l (3D) images. The volumes of the prostates were calculated from these
3D images and compared with the actual volumes. Multiple 3D ultrasoun
d volume readings were evaluated for precision. Results. The slope of
the best-fit line correlating 3D ultrasound estimated volume and true
volume was 1.006 +/- 0.007. The average error was 0.36 +/- 1.17 cm(3);
the coefficient of determination (r(2)), which is tile measure of the
straight-line relationship, was .9997; and the standard error was 1.1
5 cm(3). Conclusion. Three-dimensional ultrasound images accurately re
flect true prostate volumes measured in vitro.