C-2 EPIMERIZATION OF N-ACETYLGLUCOSAMINE IN AN OLIGOSACCHARIDE DERIVED FROM HEPARAN-SULFATE

Authors
TOIDA T VLAHOV IR SMITH AE HILEMAN RE LINHARDT RJ
Citation
T. Toida et al., C-2 EPIMERIZATION OF N-ACETYLGLUCOSAMINE IN AN OLIGOSACCHARIDE DERIVED FROM HEPARAN-SULFATE, Journal of carbohydrate chemistry, 15(3), 1996, pp. 351-360
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology
Journal title
Journal of carbohydrate chemistry → ACNP
ISSN journal
07328303
Volume
15
Issue
3
Year of publication
1996
Pages
351 - 360
Database
ISI
SICI code
0732-8303(1996)15:3<351:CEONIA>2.0.ZU;2-L
Abstract
The isolation of a heparan sulfate derived tetrasaccharide containing N-acetylmannosamine is described. The N-acetylmannosamine residue at t he reducing terminus of heparin lyase derived tetrasaccharide is forme d by base catalyzed C-2 epimerization of N-acetylglucosamine. This C-2 epimerization takes place under very mild conditions suggesting that this residue may be formed in small amounts under physiologic conditio ns.