INTEGRINS AS PROMISCUOUS SIGNAL-TRANSDUCTION DEVICES

Authors
PETTY HR TODD RF
Citation
Hr. Petty et Rf. Todd, INTEGRINS AS PROMISCUOUS SIGNAL-TRANSDUCTION DEVICES, Immunology today, 17(5), 1996, pp. 209-212
Citations number
23
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
17
Issue
5
Year of publication
1996
Pages
209 - 212
Database
ISI
SICI code
0167-5699(1996)17:5<209:IAPSD>2.0.ZU;2-P
Abstract
Recent studies suggest physical and functional interactions of glycosy lphosphatidylinositol (GPI)-linked proteins (CD14, CD16b and CD87) wit h leukocyte beta(2) integrins. As discussed in this article, it now ap pears that beta(2) integrins relay proinflammatory information from GP I-anchored membrane receptors to the cytoplasm via exodomain interacti ons.