IL-4-INDUCED IMMUNE DEVIATION AS ANTIGEN-SPECIFIC THERAPY FOR INFLAMMATORY AUTOIMMUNE-DISEASE

Authors
ROCKEN M RACKE M SHEVACH EM
Citation
M. Rocken et al., IL-4-INDUCED IMMUNE DEVIATION AS ANTIGEN-SPECIFIC THERAPY FOR INFLAMMATORY AUTOIMMUNE-DISEASE, Immunology today, 17(5), 1996, pp. 225-231
Citations number
80
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
17
Issue
5
Year of publication
1996
Pages
225 - 231
Database
ISI
SICI code
0167-5699(1996)17:5<225:IIDAAT>2.0.ZU;2-G
Abstract
Organ-specific autoimmune diseases are mediated by interferon gamma (I FN-gamma)-producing T helper 1 (Th1) cells. Here, Martin Rocken and co lleagues review the experimental basis for an antigen-specific therape utic approach to inflammatory autoimmune diseases. This strategy invol ves selective deviation of harmful Th1 responses towards an anti-infla mmatory, interleukin 4 (IL-4)-producing Th2 phenotype.