Ml. Mingus et al., PROPOFOL PERMITS TRACHEAL INTUBATION BUT DOES NOT AFFECT POSTOPERATIVE MYALGIAS, Journal of clinical anesthesia, 8(3), 1996, pp. 220-224
Study Objective. To determine the effect of propofol without succinylc
holine on intubating conditions and postoperative myalgias in ambulato
ry surgical patients undergoing general anesthesia. Design: Prospectiv
e, double-blind, randomized study. Setting: Ambulatory surgery adult p
atients. Patients: 56 ASA physical status I and II adult patients unde
rgoing general endotracheal anesthesia. Interventions: Group 1 patient
s received thiamylal plus succinylcholine, Group 2 patients received p
ropofol plus succinylcholine; and Group 3 patients received propofol p
lus saline. All patients received fentanyl, lidocaine, and nitrous oxi
de plus isoflurane in oxygen. Measurements and Main Results: Incidence
and severity of fasciculations, tracheal intubating conditions, and m
yalgias on the first and third postoperative days were measured. Propo
fol did not affect the incidence or severity of fasciculations followi
ng succinylcholine, or the incidence of myalgias. Of patients who rece
ived propofol without succinylcholine, intubation was successful in 85
%. Conclusion: Propofol did not affect the incidence or severity of po
stoperative myalgias following succinylcholine.