STRUCTURE AND SORPTION CHARACTERISTICS OF BIOAFFINITY MEMBRANES

The new bioaffinity membranes comprise mammalian blood and tissue cell s immobilized in the polymer matrix. The method of immobilization does not assume the retention of physiological and enzymatic activity of i mmobilized cells, but it ensures the safety of cellular membrane recep tors that are used as specific ligands. Macroporous polymer carriers b ased on polyacrylonitrile maintain the accessibility of the cellular r eceptors for all blood plasma components including immunoglobulins and viral particles. The sorption capacity of membranes with respect to m odel substances in a batchwise technique is evaluated. Although the re sults are of a preliminary nature, the membranes may be used in crossf low modules for selective blood plasma correction of endogenous substa nces.