HYPERPROLACTINEMIA IN SYSTEMIC LUPUS-ERYTHEMATOSUS

The objective of this project was to determine the prevalence of hyper prolactinemia (HPRL) in systemic lupus erythematosus (SLE) and to eval uate the role of prolactin (PRL) as a disease-activity marker. We dete rmined PRL in a cohort of 182 patients with SLE. Basal prolactin level s and clinical data (disease-activity index, sere-activity, medication s) were analyzed in all patients. The findings show only mildly elevat ed PRL levels in four SLE-patients and normaprolactinemia in 98% (n=17 8), without any association with disease activity.Our results differ f rom previous studies. HPRL appears not to be prevalent in SLE, nor to be associated with disease activity.