N. Kennedy et al., RANDOMIZED CONTROLLED TRIAL OF A DRUG REGIMEN THAT INCLUDES CIPROFLOXACIN FOR THE TREATMENT OF PULMONARY TUBERCULOSIS, Clinical infectious diseases, 22(5), 1996, pp. 827-833
The fluoroquinolones are promising new antituberculous agents, A rando
mized controlled trial of 200 adult patients with sputum smear-positiv
e pulmonary tuberculosis was conducted in Tanzania, Patients received
either a trial regimen (HRC) consisting of isoniazid (300 mg), rifampi
n (600 mg), and ciprofloxacin (750 mg) or a control regimen (HRZE) con
sisting of isoniazid (300 mg), rifampin (600 mg), pyrazinamide (25 mg/
kg), and ethambutol (15 mg/kg). The 168 evaluable patients all had neg
ative smears and cultures by month 6, but the time to conversion to ne
gativity was longer for the HRC group than for the HRZE group because
of the poor response of patients infected with human immunodeficiency
virus (HIV) to the HRC regimen. Relapse was more frequent in the HRC g
roup, The sterilizing activity of ciprofloxacin does not appear to be
equal to that of the combination of pyrazinamide and ethambutol, but t
he difference in outcome was significant only among HIV-infected patie
nts.