HYPERPOLARIZING SHIFT OF THE M-CURRENT ACTIVATION CURVE AFTER WASHOUTOF MUSCARINE IN BULLFROG SYMPATHETIC NEURONS

Authors
TOKIMASA T SIMMONS MA SCHNEIDER CR AKASU T
Citation
T. Tokimasa et al., HYPERPOLARIZING SHIFT OF THE M-CURRENT ACTIVATION CURVE AFTER WASHOUTOF MUSCARINE IN BULLFROG SYMPATHETIC NEURONS, Neuroscience letters, 207(2), 1996, pp. 97-100
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
207
Issue
2
Year of publication
1996
Pages
97 - 100
Database
ISI
SICI code
0304-3940(1996)207:2<97:HSOTMA>2.0.ZU;2-V
Abstract
The mechanism underlying the over-recovery of an M-type potassium curr ent following the washout of muscarine (20 mu M) has been examined. Wh ole-cell recordings were made from single neurons dissociated from bul lfrog sympathetic ganglia. During over-recovery, the maximum M-conduct ance decreased by about 2.8 nS while the steady-state M-current activa tion curve was displaced in the hyperpolarizing direction by about 13 mV. These data suggest that a hyperpolarizing shift in the kinetics of M-current causes over-recovery in amphibian autonomic neurons.