The data about the role of ifosfamide in the treatment of breast cance
r and sarcoma are summarized in the review. Ifosfamide has a higher th
erapeutic index than cyclophosphamide. Ifosfamide as single agent in b
reast cancer have shown modest activity with objective response rates
of between 20-40% depending on the level of pretreatment. Ifosfamide i
s one of the most active drugs in the treatment of metastatic soft tis
sue sarcoma.