STUDY OF ANTITUMOR-ACTIVITY AND TOXICITY OF DIOXADET

Dioxadet belongs to antitumor preparations from the group of ethylenim inotriazines. In experimental studies performed with the use of wide s pectrum of transplanted turners it revealed considerable resorptive an d contact activity. Dose-limiting side-effect of dioxadet manifests it self in the inhibition of haemopoiesis and is sufficiently reversible. Dioxadet possess no cardio-, pneumo- and nephrotoxicity. The preparat ion is notable for advantageous hydrophilic-hydrophobic balance, this allows it application both for systemic and intracavitary chemotherapy in aqueous solutions and for endolymphatic infusion and chemoemboliza tion by its oil radiopague solutions.