MULTIFOCAL PLASMACYTOMA OF HAND AND FOOT BONES

Simultaneous occurence of localized plasmacytomas of both hands and fe et has not been reported so far. Here we report a 40-year old female p atient, who had at presentation pain and deformity of hands and feet, with numerous cystic lytic lesions of phalangeal, metacarpal and metat arsal bones, detected by X-rays. The biopsy of the affected bone showe d moderately differentiated plasmacytoma of lambda light chain type (l ambda-LC). Serum and urine biochemical analysis revealed the existence of lambda-LC monoclonal component. The patient was treated by local r adiotherapy and subsequent systemic chemotherapy, which consisted of 3 cycles of the M-2 protocol and 7 cycles of melphalan-prednisone. Five years after the diagnosis, the absence of plasmacytoma was confirmed by puncture biopsy of the left hand phalanx. Monoclonal protein in ser um and urine was not detected.