Hg. Cutler et al., HOMOBOTCINOLIDE - A BIOLOGICALLY-ACTIVE NATURAL HOMOLOG OF BOTCINOLIDE FROM BOTRYTIS-CINEREA, Bioscience, biotechnology, and biochemistry, 60(4), 1996, pp. 656-658
A novel natural product exhibiting biological activity was isolated fr
om a strain of Botrytis cinerea that had infected raspherry fruit (Rub
us ideaus). Liquid fermentation and bioassay-directed fractionation of
the organism yielded a compound with molecular formula C22H38O8 that
is trivially named homobotcinolide. It significantly inhibited etiolat
ed wheat coleoptile growth. Greenhouse-grown bean, corn, and tobacco p
lants mere also affected by exogenous applications of homobotcinolide,
severe chlorosis and necrosis being exhibited in corn. The compound i
s a polyhydroxylated nonalactone esterified with 4-hydroxy-2-decenoic
acid.