INVERSE RELATIONSHIP BETWEEN HOMOSERINE DEHYDROGENASE-ACTIVITY AND URIDINE PRODUCTIVITY IN A PYRIMIDINE ANALOG-RESISTANT MUTANT OF BACILLUS-SUBTILIS

Authors
DOI M KAWANO A ASAHI S
Citation
M. Doi et al., INVERSE RELATIONSHIP BETWEEN HOMOSERINE DEHYDROGENASE-ACTIVITY AND URIDINE PRODUCTIVITY IN A PYRIMIDINE ANALOG-RESISTANT MUTANT OF BACILLUS-SUBTILIS, Bioscience, biotechnology, and biochemistry, 60(4), 1996, pp. 672-673
Citations number
6
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
60
Issue
4
Year of publication
1996
Pages
672 - 673
Database
ISI
SICI code
0916-8451(1996)60:4<672:IRBHDA>2.0.ZU;2-Z
Abstract
A uridine-overproducing mutant of Bacillus subtilis was found to requi re homoserine for growth due to a defect of homoserine dehydrogenase. When the mutant reverted back to prototropy, the production of uridine was decreased by about 40%; the decrease was, however, restored to an appreciable extent by adding aspartic acid, the common precursor for the biosynthesis of homoserine and UMP.