DUODENAL CARCINOIDS - A STATISTICAL EVALUATION OF 635 CASES COLLECTEDFROM THE LITERATURE

This statistical study was performed to clarify the characteristic fea tures of duodenal carcinoids and supply researchers in this field with new detailed and reliable information for their subsequent investigat ion. In the statistical analysis of 635 cases of duodenal carcinoids c ollected from the world literature, the following characteristics were disclosed. The significant preponderance was found in the first porti on of the duodenum as sites of the lesions, small tumor-size of 10 mm or less, lymph nodes as the site of metastases, the B growth pattern o f histology, the submucosa as the depth of invasion, somatostatin prod uction detected by immunohistochemistry, gastric cancer as the associa tion of chronological dual malignancy, von Recklinghausen's neurofibro matosis, and psammoma bodies in neoplastic glandular spaces. Among the se, it was in particular emphasized that somatostatin production along with psammoma bodies in glandular structures should be evaluated in c ases of duodenal carcinoid (carcinoid somatostatinoma).