IN-VITRO EFFECT OF HYPERTHERMIA COMBINED WITH CISPLATIN (CDDP) OR (GLYCOLATO-O,O')-DIAMMINE PLATINUM (254-S) ON HUMAN GINGIVAL CARCINOMA CELL-LINE CA-9-22

Authors
OHTSUBO T SAITO H TANAKA N HAYASHI S UEDA K KANO E
Citation
T. Ohtsubo et al., IN-VITRO EFFECT OF HYPERTHERMIA COMBINED WITH CISPLATIN (CDDP) OR (GLYCOLATO-O,O')-DIAMMINE PLATINUM (254-S) ON HUMAN GINGIVAL CARCINOMA CELL-LINE CA-9-22, Journal of experimental & clinical cancer research, 15(1), 1996, pp. 37-42
Citations number
19
Categorie Soggetti
Oncology
Journal title
Journal of experimental & clinical cancer research → ACNP
ISSN journal
03929078
Volume
15
Issue
1
Year of publication
1996
Pages
37 - 42
Database
ISI
SICI code
0392-9078(1996)15:1<37:IEOHCW>2.0.ZU;2-1
Abstract
The interactive effects of hyperthermia combined with CDDP (1.0 mu g/m l) or 254-S (1.0 mu g/ml) were examined on the surviving fractions of human gingival carcinoma Ca-9-22 cells. Both CDDP and 254-S treatment induced a slight enhancement in thermosensitivity of thermotolerant ce lls, The development of thermotolerance during step-up heating was par tially inhibited by simultaneous treatment with CDDP or 254-S througho ut the heating process. Simultaneous heat treatment at 42 degrees C wi th either drug showed marked interactive effect.