THE ROLE OF BETA(2)-GLYCOPROTEIN-I IN THE ANTIPHOSPHOLIPID SYNDROME

Authors
KRILIS SA SHENG YH KANDIAH DA
Citation
Sa. Krilis et al., THE ROLE OF BETA(2)-GLYCOPROTEIN-I IN THE ANTIPHOSPHOLIPID SYNDROME, Lupus, 5(2), 1996, pp. 150-152
Citations number
16
Categorie Soggetti
Rheumatology
Journal title
Lupus → ACNP
ISSN journal
09612033
Volume
5
Issue
2
Year of publication
1996
Pages
150 - 152
Database
ISI
SICI code
0961-2033(1996)5:2<150:TROBIT>2.0.ZU;2-I
Abstract
Antiphospholipid antibodies were originally thought to bind negatively -charged (aniomic) phospholipids. Current evidence suggests that the t arget antigen is considerably more complex and includes beta(2)-glycop rotein I, a phospholipid-binding plasma protein. Our understanding of the pathophysiology of the antiphospholipid syndrome has increased exp onentially with a number of studies into the interactions of antiphosp holipid antibodies and beta(2)-glycoprotein I.