SYNTHESIS OF CARBAZOLE DERIVATIVES .3. SYNTHESIS OF NEW PYRROLIDINO[3,4-C]CARBAZOLES BY INTRAMOLECULAR MICHAEL ADDITION

Authors
MAHBOOBI S KUHR S KOLLER M
Citation
S. Mahboobi et al., SYNTHESIS OF CARBAZOLE DERIVATIVES .3. SYNTHESIS OF NEW PYRROLIDINO[3,4-C]CARBAZOLES BY INTRAMOLECULAR MICHAEL ADDITION, Tetrahedron, 52(18), 1996, pp. 6373-6382
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
18
Year of publication
1996
Pages
6373 - 6382
Database
ISI
SICI code
0040-4020(1996)52:18<6373:SOCD.S>2.0.ZU;2-Z
Abstract
We have reported on the synthesis of carbazoles by inter- and intramol ecular Michael addition. Ellipticine derivatives are related to these compounds, and especially those with 9-methoxy- and 9-hydroxy substitu ents exhibit appreciable antitumor and antileukemic activity. Therefor e, we have prepared the tetrahydrocarbazoles 7a and 7b, starting from N-benzyl-2-formyl-5-methoxyindole (2a) and N-benzyl-2-formyl-7-methoxy indole (2b), respectively. Copyright (C) 1996 Published by Elsevier Sc ience Ltd