Recent discoveries emanating from basic electrophysiological, anatomic
al, and pharmacological studies have implications for the diagnosis an
d treatment of clinical disorders of eye movements caused by disease a
ffecting the brainstem and cerebellum, Electrophysiological studies ha
ve better defined the role of the superior colliculus in programming o
f saccades, and the nucleus reticularis tegmenti pontis in saccade-ver
gence interaction. Pharmacological inactivation studies have demonstra
ted the important role played by gamma-aminobutyric acid in the normal
control of gaze and lead to trials of new agents in the treatment of
nystagmus.