DOSE OPTIMIZATION IN CLINICAL ONCOLOGY - PHARMACOKINETIC-PHARMACODYNAMIC RELATIONSHIPS

The establishment of relationships between pharmacokinetics and pharma codynamics of anticancer drugs might allow to individualize the dosing of these drugs. Our knowledge of this kind of relationship has grown markedly in recent years. After a review of the different causes of va riability in pharmacokinetics and pharmacodynamics of these drugs, the different models used for establishing these correlations were analyz ed and criticized. Finally, the three methods for adapting drug dosing based on pharmacokinetic data were proposed and the main applications of these concepts were reviewed.