SEVERE 5-FLUOROURACIL TOXICITY IN A BREAS T-CANCER PATIENT WITH CONCURRENT OSTEOGENESIS IMPERFECTA AND DEHYDROGENASE-DEFICIENCY

Dihydropyrimidine dehydrogenase (DPD) is the principal enzyme involved in the catabolism of 5 fluorouracil (5 FU). The clinical importance o f DPD has recently been demonstrated wit the identification of rare ca ses presenting a severe toxicity to 5 FU related to proven DPD deficie ncy. We report a new case in a patient with concurrent congenital oste ogenesis imperfecta We were surprised to fmd another similar associati on reported by Lyss. It is tempting to speculate that DPD activity may be abnormally regulated in osteogenesis imperfecta patients.