UNUSUAL PRESENTATION OF EWING SARCOMA WITH T(21-22) IN A 3-YEAR-OLD BOY

Purpose: We describe a 3-year-old boy with widespread, metastatic Ewin g sarcoma and an unusual translocation, involving chromosomes 21 and 2 2. Materials and Methods: Cytogenetic studies were performed on a biop sy of the primary tumor. These included GTG banding and fluorescence i n situ hybridization. Results: A balanced translocation between chromo somes 21 and 22 was noted with translocation breakpoints at bands 21q2 2 and 22q12. Conclusions: The t(21;22) translocation represents a new cytogenetic abnormality that may be associated with Ewing sarcoma. Its prognostic significance, if any, remains to be determined.