LYMPHOBLASTIC LYMPHOMA FOLLOWING PRENATAL EXPOSURE TO PHENYTOIN

Citation
Jc. Murray et al., LYMPHOBLASTIC LYMPHOMA FOLLOWING PRENATAL EXPOSURE TO PHENYTOIN, Journal of pediatric hematology/oncology, 18(2), 1996, pp. 241-243
Citations number
23
Categorie Soggetti
Oncology,Hematology,Pediatrics
ISSN journal
10774114
Volume
18
Issue
2
Year of publication
1996
Pages
241 - 243
Database
ISI
SICI code
1077-4114(1996)18:2<241:LLFPET>2.0.ZU;2-S
Abstract
Purpose: Oncogenesis has been associated with prenatal exposure to phe nytoin, concomitant with or independent of the fetal hydantoin syndrom e. The majority of reported cases have been embryonal tumors of neural crest origin and have occurred in the first 3 years of life. Patients and Methods: We report a boy who was exposed to phenytoin throughout gestation and later developed T-lymphocyte lymphoblastic lymphoma, a p reviously unreported malignancy associated with in utero phenytoin exp osure. Previously reported cases of neoplasia occurring after such exp osure are tabulated. Conclusion: The actual transplacental oncogenic p otential of phenytoin and the epidemiology of this association are poo rly understood. Phenytoin-induced alterations in lymphocyte-mediated i mmunosurveillance or oxidative metabolic clearance may he etiologic. I nquiry into prenatal phenytoin exposure should be done in any child wh o develops cancer, especially those who develop a rare tumor or presen t with a more common tumor at an unusually young age. Continued docume ntation of such cases will advance the understanding of phenytoin-asso ciated transplacental oncogenesis.