DNA VACCINES, CYBERSPACE AND SELF-HELP PROGRAMS

Occasionally, a major change in vaccine methodology comes along. Such would appear to be the case with the advent of DNA-mediated immunizati on, colloquially known as DNA vaccines. This represents a radical new way to Occasionally, a major change in vaccine methodology comes along . Such deliver antigens; it involves the direct introduction of a plas mid DNA encoding an antigenic protein which is then expressed within c ells of the organism. This leads to surprisingly strong immune respons es, involving both the humoral and cellular arms of the immune system. DNA-mediated immunization to a single antigen can provide protection against infection by a pathogen. Here, a guide is provided comprising twelve steps to help design and carry out DNA-mediated immunization. T his approach to immunization will greatly facilitate studies of immuno physiological responses to antigens of pathogenic organisms. An Intern et site (URL: http://www.genweb.com/Dnavax/dnav ax.html) has been crea ted to help promote this potentially revolutionary approach to vaccina tion in the service of public health.