BIOCHEMICAL AND PATHOLOGICAL-STUDIES IN EXPERIMENTAL DICHLORVOS TOXICITY IN BUBALUS-BUBALIS

Male buffalo calves (10) were divided into 2 groups of 5 animals each. Animals of one group were administered dichlorvos orally @ 4 mg/kg bo dy weight daily for 21 days, whereas the other group was kept as contr ol. The intoxicated animals showed mild subacute toxic symptoms includ ing depression, ataxia and increased secretions/excretions. A marked i nhibition of plasma cholinesterase and tissue carboxylesterase and pho sphatases in both, plasma and tissues was observed. Glucose, urea nitr ogen, cholesterol, total proteins and immunoglobulins in the blood als o increased significantly till the end of the experiment. Lungs showed peribronchial lymphoid hyperplasia, mild interstitial pneumonia, necr otic hepatitis, nephritis, myocarditis, gastritis and myositis with in filtration of mononuclear cells. Cerebellum revealed meningoencephalit is and cerebellum showed necrosis of Purkinje cells. The control calve s showed neither anp significant biochemical change in the blood and t issues nor any pathological change in various organs.