IFOSFAMIDE NEPHROTOXICITY IN CHILDREN - HISTOPATHOLOGICAL FEATURES IN2 CASES

Authors
MORLAND BJ MANN JR MILFORD DV RAAFAT F STEVENS MCG
Citation
Bj. Morland et al., IFOSFAMIDE NEPHROTOXICITY IN CHILDREN - HISTOPATHOLOGICAL FEATURES IN2 CASES, Medical and pediatric oncology, 27(1), 1996, pp. 57-61
Citations number
17
Categorie Soggetti
Oncology,Pediatrics
Journal title
Medical and pediatric oncology → ACNP
ISSN journal
00981532
Volume
27
Issue
1
Year of publication
1996
Pages
57 - 61
Database
ISI
SICI code
0098-1532(1996)27:1<57:INIC-H>2.0.ZU;2-F
Abstract
We report on two children with rhabdomyosarcoma who received ifosfamid e as part of their chemotherapy schedule. Both children subsequently d eveloped severe ifosfamide-induced nephrotoxicity, necessitating elect rolyte supplementation. We describe the histopathological findings of renal biopsies performed in these children after the onset of renal dy sfunction and comment on the possible mechanisms involved in ifosfamid e nephrotoxicity. (C) 1996 Wiley-Liss, Inc.