ANTI-TNF TREATMENT REVERTS INCREASED MUSCLE UBIQUITIN GENE-EXPRESSIONIN TUMOR-BEARING RATS

Implantation of the ascitic tumour Yoshida AH-130 hepatoma (a cachecti c tumour) resulted in important increases in muscle ubiquitin gene exp ression. Administration of daily injections of 25 mg/kg b.w. polyclona l goat anti-murine TNF IgG preparation to tumour-bearing rats abolishe d the increase in muscle ubiquitin gene expression observed in the con trol (non-anti-TNF-treated) tumour-bearing rats. It is concluded that TNF can have an important role in the activation of the ubiquitin-depe ndent proteolytic system during tumour growth. (C) 1996 Academic Press , Inc.