NOVEL POLYPEPTIDES INDUCED BY THE INSECTICIDE LINDANE (GAMMA-HEXACHLOROCYCLOHEXANE) ARE REQUIRED FOR ITS BIODEGRADATION BY A SPHINGOMONAS-PAUCIMOBILIS STRAIN
Tk. Adhya et al., NOVEL POLYPEPTIDES INDUCED BY THE INSECTICIDE LINDANE (GAMMA-HEXACHLOROCYCLOHEXANE) ARE REQUIRED FOR ITS BIODEGRADATION BY A SPHINGOMONAS-PAUCIMOBILIS STRAIN, Biochemical and biophysical research communications, 221(3), 1996, pp. 755-761
When exposed to the potent insecticide gamma-hexachlorocyclohexane or
lindane, a Sphingomonas paucimobilis strain rapidly synthesised 7 nove
l polypeptides and concomitantly gained the ability to degrade lindane
. Synthesis of these proteins was switched-off subsequent to the disap
pearance of lindane from the medium. Treatments which induced the synt
hesis of identical proteins also conferred on cells the ability to deg
rade lindane. In contrast, cells blocked in protein synthesis could no
t be induced to degrade lindane. The close correspondence observed bet
ween expression of lindane-induced proteins and gamma-hexachlorocycloh
exane catabolism strongly implicates these novel proteins in lindane b
iodegradation. (C) 1996 Academic Press, Inc.