EFFECT OF TREATMENT OF PALATAL INFLAMMATORY PAPILLARY HYPERPLASIA WITH LOCAL AND SYSTEMIC ANTIFUNGAL AGENTS ACCOMPANIED BY RENEWAL OF COMPLETE DENTURES

The aim of this study was to estimate the effect of local and systemic antifungal treatment, accompanied by renewal of complete dentures, on palatal inflammatory papillary hyperplasia (PIPH). The treatment grou ps consisted of 26 subjects treated with a local antifungal agent (mic onazole, 2% gel) for 4 weeks and 13 subjects treated with a systemic a ntifungal agent (fluconazole, 50 mg) for 2 weeks (test groups). Ten su bjects fitted with new complete dentures served as a control group. Va riables examined before antifungal and prosthetic treatment included e stimation of the size and color of the affected palatal area, measurem ents of the lengths of the papillae, and salivary variables. Six month s after the completion of prosthetic treatment healing was determined as disappearance or marked reduction of the redness of the PIPH. Heali ng was more often observed in test groups (64%) than in the control gr oup (20%) (P=0.012). Fifty-eight per cent of the subjects treated with a local (miconazole, 2%) and 77% of those treated with a systemic (fl uconazole, 50 mg) antifungal agent were healed. Even though papillary hyperplastic tissue did not disappear, the treatment of PIPH with an a ntifungal agent without surgery before renewal of dentures might be an alternative treatment in mild cases.