LUJAN-FRYNS SYNDROME IN THE DIFFERENTIAL-DIAGNOSIS OF SCHIZOPHRENIA

Schizophrenia is considered to be a heterogenous disorder. Different e tiopathological mechanisms can be attributed to a similar clinical pic ture as described in DSM-III-R criteria. We present a case of a young man diagnosed on different occasions as schizophrenic with mild mental retardation, Clinical examination revealed signs and symptoms most co mpatible with the diagnosis of Lujan-Fryns syndrome, an X-linked menta l retardation syndrome with marfanoid features, frequently associated with psychotic or other psychiatric symptoms. In all patients with sym ptoms of schizophrenia and mental retardation Lujan-Fryns syndrome sho uld be considered in the differential diagnosis. (C) 1996 Wiley-Liss, Inc.