SYNTHESIS OF TRIMETHYLAMINE-[C-14]CARBOXYBORANE AND TRIMETHYLAMINE-[C-14]CARBOXYMETHOXYBORANE AND L1210 LEUKEMIA-CELL UPTAKE

Authors
CHEN SY BURNHAM BS SPIELVOGEL BF SOOD A WYRICK SD HALL IH
Citation
Sy. Chen et al., SYNTHESIS OF TRIMETHYLAMINE-[C-14]CARBOXYBORANE AND TRIMETHYLAMINE-[C-14]CARBOXYMETHOXYBORANE AND L1210 LEUKEMIA-CELL UPTAKE, Applied organometallic chemistry, 10(3-4), 1996, pp. 279-282
Citations number
10
Categorie Soggetti
Chemistry Applied","Chemistry Inorganic & Nuclear
Journal title
Applied organometallic chemistry → ACNP
ISSN journal
02682605
Volume
10
Issue
3-4
Year of publication
1996
Pages
279 - 282
Database
ISI
SICI code
0268-2605(1996)10:3-4<279:SOTAT>2.0.ZU;2-7
Abstract
The anti-neoplastic agents trimethylamine-carboxyborane and its corres ponding methyl ester have successfully been radiolabeled with carbon-1 4 in the carboxyl group. Using the radiolabeled agents we have shown t hat their L1210 leukemia cell uptake appeared to be by a passive proce ss and binding of the agents to DNA, RNA and protein over 24 h was min imal.