THE PERFORMANCE OF E23(FV)PES, RECOMBINANT TOXINS TARGETING THE ERBB-2 PROTEIN

Authors
KING CR FISCHER PH RANDO RF PASTAN I
Citation
Cr. King et al., THE PERFORMANCE OF E23(FV)PES, RECOMBINANT TOXINS TARGETING THE ERBB-2 PROTEIN, Seminars in cancer biology, 7(2), 1996, pp. 79-86
Citations number
48
Categorie Soggetti
Oncology
Journal title
Seminars in cancer biology → ACNP
ISSN journal
1044579X
Volume
7
Issue
2
Year of publication
1996
Pages
79 - 86
Database
ISI
SICI code
1044-579X(1996)7:2<79:TPOERT>2.0.ZU;2-A
Abstract
The overexpression of the erbB-2 (HER-2, neu) gene has attracted signi ficant interest as a molecular target for the rational design of cance r therapies. This review examines the design and preclinical testing p hase for one such experimental therapy, recombinant toxins targeted to the erbB-2 protein, termed e23(Fv)PEs.