CCK-4 RESTRICTED ANALOGS CONTAINING A 3-OXOINDOLIZIDINE SKELETON

Authors
GONZALEZMUNIZ R DOMINGUEZ MJ MARTINMARTINEZ M HERRANZ R GARCIALOPEZ MT BARBER A BALLAZ S DELRIO J
Citation
R. Gonzalezmuniz et al., CCK-4 RESTRICTED ANALOGS CONTAINING A 3-OXOINDOLIZIDINE SKELETON, Bioorganic & medicinal chemistry letters, 6(8), 1996, pp. 967-972
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
8
Year of publication
1996
Pages
967 - 972
Database
ISI
SICI code
0960-894X(1996)6:8<967:CRACA3>2.0.ZU;2-L
Abstract
A series of CCK-4 restricted analogues, incorporating a 3-oxoindolizid ine bicyclic lactam as conformational constraint, is described. The 8- (Boc-tryptophyl)amino-2-benzyl derivatives behave as weak CCK-A or CCK -B receptor antagonists. The main factors for selectivity are the conf iguration at C-2 position of the 3-oxoindolizidine ring and at the Trp residue. Copyright (C) 1996 Elsevier Science Ltd