SYNTHESIS AND EVALUATION OF A BETA-LACTAM-CONTAINING DIPEPTIDE ANALOGAS A PROTEASE INHIBITOR

Authors
WU ZJ GEORG GI CATHERS BE SCHLOSS JV
Citation
Zj. Wu et al., SYNTHESIS AND EVALUATION OF A BETA-LACTAM-CONTAINING DIPEPTIDE ANALOGAS A PROTEASE INHIBITOR, Bioorganic & medicinal chemistry letters, 6(8), 1996, pp. 983-986
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
8
Year of publication
1996
Pages
983 - 986
Database
ISI
SICI code
0960-894X(1996)6:8<983:SAEOAB>2.0.ZU;2-R
Abstract
A monocyclic 3-amino-beta-lactam analog of the dipeptide Phe-Gly methy l ester has been synthesized as a potential protease inhibitor. This b eta-lactam is a non-time-dependent inhibitor of alpha-chymotrypsin, ca rboxypeptidase Y, and cathepsin G. Copyright (C) 1996 Elsevier Science Ltd