Introduction. Birth of an Harlequin fetus in an African maternity ward
is an exceptional event. There is no question as to the diagnosis, bu
t no treatment is available. Case report. A female infant was delivere
d with typical lesions of malignant keratoma. Death occurred 20 hours
after birth. Discussion. In countries with adequate intensive care fac
ilities (hydration, acitretine), such infants may occasionnally surviv
e with the risk of developing major lamellar ichthyosis which remains
a handicap for the rest of life. In Burkina-Faso, such therapeutic fac
ilities are lacking as are means of antenatal diagnosis. The ethical q
uestion as to whether or not to attempt survival measures is quire dif
ferent under these conditions.