COMPARABILITY OF RP-HPLC RETENTION INDEXES OF DRUGS IN 3 DATABASES

Three databases of HPLC retention indices in the 1-nitroalkane scale w ere recently established (IFM = Institute of Forensic Medicine, MCL = Microchemistry Laboratory, MTSS = Merck Tox Screening System). In two of them (IFM and MTSS) virtually identical chromatographic conditions were applied but different RP-columns. In the third system (MCL) a dif ferent column and different elution conditions were used. Among a tota l of 1149 drugs examined in all three labs, 258 drugs were common for LFM and MTSS, 179 were common for MCL and MTSS, 162 were common for IF M and MCL, and 135 drugs were common for all three databases.