Jw. Pasman et al., THE EFFECTS OF EARLY AND LATE PRETERM BIRTH ON BRAIN-STEM AND MIDDLE-LATENCY AUDITORY-EVOKED RESPONSES IN CHILDREN WITH NORMAL NEURODEVELOPMENT, Journal of clinical neurophysiology, 13(3), 1996, pp. 234-241
In preterm and term infants, brainstem and middle latency auditory evo
ked responses (ABR and MLR) were obtained at 40 and 52 weeks conceptio
nal age (CA) and at 5 years of age. A neurological and neuropsychologi
cal evaluation was performed at 5 years of age. To study the effect of
preterm birth on the maturation of the ABR and MLR, the preterm infan
ts were divided into early and late preterm groups. Only children with
a normal neurodevelopmental outcome at 5 years of age were entered in
to the study. For ABR, the late preterm group showed significantly lon
ger mean latencies IIc, III, V, and Vc when compared with the term gro
up at 52 weeks CA. There was a trend to longer ABR latencies I in the
early preterm group compared with the term group. At 52 weeks CA, the
late preterm group showed longer mean interpeak latencies III-I and V-
I when compared with the term as well as the early preterm group. At 5
years, the late preterm group showed significantly longer mean ABR la
tencies IIc and III when compared to the early preterm group. For MLR,
the early preterm group showed significantly longer mean latencies of
MLR component PO when compared with the term group at 40 weeks CA. At
52 weeks, the late preterm group also had longer mean MLR latencies P
O than the term group. At 5 years of age, the term group showed higher
mean peak-to-peak amplitudes Na-PO than the early as well as the late
preterm group. To a large extent, the ABR results support the hypothe
sis that middle ear effusions in combination with retarded myelination
of the central auditory pathway are responsible for the ABR differenc
es found between term and preterm infants with a normal neurodevelopme
ntal outcome at 5 years of age. The longer latencies and interpeak lat
encies found in late preterm infants when compared with early preterm
infants might be explained by an augmented vulnerability of the audito
ry pathway between 30 and 34 weeks CA. The MLR differences found betwe
en term and preterm infants might be explained by a difference in the
maturation of primary and nonprimary MLR components.