STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF RETINOID CANCER INHIBITION

Authors
JAEGER EP JURS PC STOUCH TR
Citation
Ep. Jaeger et al., STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF RETINOID CANCER INHIBITION, European journal of medicinal chemistry, 28(4), 1993, pp. 275-290
Citations number
52
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
28
Issue
4
Year of publication
1993
Pages
275 - 290
Database
ISI
SICI code
0223-5234(1993)28:4<275:SRSORC>2.0.ZU;2-O
Abstract
A structure-activity relationship (SAR) is described between 152 retin oid structures and their biological activity in an in vitro test that correlates with cancer prophylaxis. Using 18 molecular features, multi variate analysis was used to build and evaluate an SAR that correctly classified 94% of the 152 structures. Blind studies correctly predicte d the biological activities of 17 of 19 new compounds (89%).