ABSORPTION OF SULINDAC FROM A NOVEL (PRO-SORB(TM)) LIQUID FORMULATION

The absorption of sulindac from two different 200 mg oral dosage forms , Pro-Sorb(TM) liquid and Clinoril(R) tablets, was compared following administration to eight healthy human volunteers. Subjects received bo th formulations according to a randomized crossover design and blood s amples were collected at selected times during 24 h. Concentrations of both sulindac and its active sulphide metabolite were determined by H PLC and individual serum concentration versus time profiles were const ructed. Maximal serum concentrations (C-max) and area under the curve values (AUC(last) and AUC(0-infinity)) were compared for both sulindac and sulindac sulphide. The results indicate that the rate and extent of absorption of sulindac from Pro-Sorb(TM) liquid are significantly g reater than those from Clinoril(R) tablets, a finding consistent with the observation that the liquid form produces less gastric irritation following oral administration.